This hypothesis was laid by Dr.Simeon few decades back and he performed clinical studies for the same observed very good and significant results.

Dr Simeons was a graduate of the University of Heidelberg Medical School in the 1920s. He chose endocrinology as his speciality, which in turn led to a fascination with tropical diseases such as malaria, dengue fever and leprosy. Simeons spent several years in Hamburg, focusing on the diagnosis and treatment of such diseases. In 1928, he travelled to central Africa to study these diseases personally. In 1931, Dr Simeons accepted a post in India, where he spent the next two decades. While there, he developed the use of the drug Atabrine, which became and remained for years a mainstay of conventional antimalarial treatment. He also investigated a new method of blood staining to better observe the malaria parasite. For his work against malaria, Dr Simeons was awarded the Order of Merit by the Red Cross. During World War II, he held several important Indian government posts, conducted extensive research on bubonic plague and also developed model centres for the treatment of leprosy.

After India became independent, Dr Simeons set up in private practice in Bombay (now Mumbai). In 1949, with his wife and three sons, Dr Simeons moved to Rome, where he worked on psychosomatic disorders at the Salvator Mundi International Hospital. He was regarded as one of the top research doctors in Europe. Although much of his early work was concerned with the infectious diseases malaria, leprosy and bubonic plague, psychosomatic disorders were another of Dr Simeons' interests.

As he travelled the world, Dr Simeons became fascinated with the condition of obesity, which was a relatively rare condition at that time. His research would lead him to investigate the links between endocrinology, obesity and psychosomatic disorders.

He studied every potential solution for obesity offered anywhere in the world. As part of his thorough investigation , he researched the thyroid, pituitary and adrenal glands, the pancreas, the gallbladder and over 100 other physiological functions. He could find no direct correlation between obesity and these various glands and organs. Dr Simeons finally concluded that the key to the obesity problem lies within the part of the brain called the diencephalon, a complex of structures that includes the thalamus and hypothalamus. It is particularly the compromised function of the hypothalamus, he discovered, that is at the core of the problem. According to Dr Simeons: "If obesity is always due to one very specific diencephalic deficiency, it follows that the only way to cure it is to correct this deficiency. At first this seemed an utterly hopeless undertaking. The greatest obstacle was that one could hardly hope to correct an inherited trait localised deep inside the brain, and while we did possess a number of drugs whose point of action was believed to be in the diencephalon, none of them had the slightest effect on the fat centre. There was not even a pointer showing a direction in which pharmacological research could move to find a drug that had such a specific action."

While it was commonly believed that overeating causes obesity, Simeons found that overeating is the result of a metabolic disorder-not its cause.

Now that he had discovered the long-sought-after cause, Dr Simeons was in pursuit of a solution. His "Eureka moment" came when he noticed that very thin pregnant Indian women, although having a low-caloric intake while at the same time doing demanding physical activity, delivered healthy full-weight babies. These pregnant women could easily lose weight by drastically reducing their dietary intake but without feeling hungry or in any way harming the child in the womb. After much research, he attributed this phenomenon to the presence of a substance called human chorionic gonadotrophin (hCG), which is made in high amounts in a woman's body during pregnancy.

He also reflected on the rare medical condition of young obese Indian boys, known as "fat boys", who were cured of their obesity with daily injections of small amounts of hCG: they miraculously lost their ravenous appetites and reshaped their bodies to normal.

Dr Simeons wondered if hCG could assist in opening the abnormal, secure reserves of fat in non-pregnant women and possibly even in men. Under normal conditions, these abnormal fat reserves are almost impossible to access and are only released as the body's last survival strategy during times of extreme starvation. However, Dr Simeons found one very interesting exception: hCG signals the body to mobilise these fat reserves. At his hospital, he experimented with this approach, using daily hCG injections combined with a very specific 500-calories-per-day diet. After many years of working with thousands of test patients, he perfected his "weight loss cure protocol". The results were astonishing. Almost 100 per cent of his patients were losing approximately one pound (0.5 kilogram) per day while on the protocol. And they were only losing the most difficult and resistant form of body fat, i.e., abnormal stored fat.